The research aims at enhanced predictive understanding of biospheric, hydrospheric and atmospheric (BHA) interactions, including their response to global climate and land-use change. The focus is on the regional scale in climatically sensitive, and socio-economically significant regions, such as mountain areas, semi-arid regions, conurbations (megacities). To achieve this overarching goal, fundamental processes from the molecular scale, extended ecosystems, to the regional scale is studied. Work is based on manipulative experiments, instrument development, as well as observational and modelling techniques. Synthesis of process ensembles across scales is achieved by massively coupled BHA-climate models, as the basis for climate change impact studies, to study the regional expression of global climate change scenarios on water resources, air quality, tourism, agro- and silviculture.